Stem Cell Therapy Shows Promise For COPD, But Questions Remain

Chronic Obstructive Pulmonary Disease (COPD) is a lung disease that causes shortness of breath. Liu ZJ, Zhuge Y, Velazquez OC. Trafficking and differentiation of mesenchymal stem cells. Milman Krentsis I, Rosen C, Shezen E, Aronovich A, Nathanson B, Bachar-Lustig E, et al. Lung injury repair by transplantation of adult lung cells following preconditioning of recipient mice.

The current systematic review and meta-analysis suggest a promising role for MSC administration in COPD treatment. However, like embryonic stem cells, they're able to create tissue for other organs and body structures. Tibboel J, Keijzer R, Reiss I, de Jongste JC, Post M. Intravenous and intratracheal mesenchymal stromal cell injection in a mouse model of pulmonary emphysema.

Researchers delivered stem cells intravenously to b-ENaC overexpressing mice at 4 and 6 weeks of age, before collecting samples tissue and cells from the lungs at 8 weeks. Emphysema is the destruction of the tissue can you be cured of copd in and surrounding the alveoli in the lungs, which are small fluid-filled sacs responsible for oxygen exchange processes within the lungs.

Contributions: (I) Conception and design: All authors; (II) Administrative support: None; (III) Provision of study materials or patients: None; (IV) Collection and assembly of data: None; (V) Data analysis and interpretation: Z Sun; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.

UCSF assistant professor of medicine Tien Peng , MD, is using genetic information about COPD to guide the development of novel treatments for the disease. Early clinical studies have shown that the MSCs can be safely administered (5,10-12). Although this is a pilot study, these primary results provide an important and significant basis for further clinical investigations of MSCs in patients with COPD.

Adult stem cells can be obtained from the patient's fat cells. See how Regenestem's Stem Cell Therapies have worked for thousands of people suffering from a variety of ailments, such as COPD. Autologous stem cell therapy may offer hope for patients with chronic obstructive pulmonary disease (COPD).